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Hoag leads innovative clinical trials, including immunotherapy agents, all pushing for more advanced, effective care for esophageal cancer patients.





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Contact usComprehensive evaluation with accurate diagnosis is the foundation for achieving highly successful outcomes. That’s why it’s important to seek care from a center that provides academic level care from a multidisciplinary, specialized team of gastroesophageal experts experienced in the accurate diagnosis and staging of esophageal cancer, as well as other complex gastroesophageal diseases.
Beginning with a thorough evaluation that includes a comprehensive physical exam, personal medical history review and state-of-the-art diagnostic workup, Hoag’s multidisciplinary team of board-certified, fellowship trained gastrointestinal experts carefully evaluate and pinpoint the nature of the cancer, so the most appropriate personalized treatment options can be employed.
Hoag’s state-of-the-art diagnostic technologies provide our team with the latest modalities in the accurate diagnosis of esophageal cancer and other disorders. Some of the progressive imaging studies that may be utilized include:
Barium swallow X-ray is an imaging study in which a liquid is swallowed that coats the lining of the esophagus. This makes the esophagus stand out on the X-ray so that physicians can identify certain problems, including cancers of the esophagus.
Endoscopy is a minimally invasive procedure that allows a physician to look inside the esophagus, stomach, and duodenum (part of the small intestine). During an upper endoscopy, a thin, lighted tube called an endoscope is carefully guided down the esophagus. The endoscope transmits a high definition image to a monitor, so the physician can view the lining of these organs. Many times, a sample of tissue is obtained during this procedure for biopsy.
Endoscopic Ultrasound (EUS) combines endoscopy and ultrasound in order to obtain images of the digestive tract and the surrounding tissue and organs. Often, EUS is used to obtain tissue samples used in biopsy and for staging cancers.
Positron Emission Tomography (PET) is used to identify malignant cells even before an actual lesion (lump) can be detected in a physical exam, or on a CT or MRI scan.
Computed Tomography (CT) utilizes state-of-the-art x-rays to help determine the extent of the cancer and whether it encompasses the surrounding organs.
Biopsy is the removal of a sample of tissue for testing. This procedure is performed to definitively diagnose esophageal cancer, and usually takes place via endoscopic ultrasound. It’s important to note that proper diagnosis and staging of esophageal cancer is critical to developing a successful treatment plan. That’s why it’s so important to seek proper evaluation and treatment from a healthcare expert experienced in the most advanced gastroesophageal cancer care.
EsoGuard is a first-in-the-nation, non-invasive esophageal DNA test that detects early cellular changes linked to esophageal disease—without the discomfort of traditional endoscopy. Ideal for individuals at higher risk, this innovative screening uses a swallowable capsule to collect cells for lab analysis, helping identify Barrett’s esophagus early and potentially reducing esophageal cancer risk by up to 90%.
When it comes to esophageal cancer and other gastrointestinal diseases, Hoag Family Cancer Institute and Hoag Digestive Health Institute team up to provide a full array of progressive treatment options. As a recognized leader and high-volume provider of innovative gastroesophageal care, Hoag’s multidisciplinary team of digestive disease experts performs some of the most advanced gastroesophageal procedures available in the nation with clinical outcomes that rival national figures.
Hoag continues to lead the way in complex gastroesophageal care, providing access to a highly specialized surgical team that works collaboratively with Hoag-affiliated thoracic surgeons, gastroenterologists and medical oncology specialists to provide academic-level care. Hoag’s committed to accurate diagnosis, combined with progressive therapeutic options enables Hoag patients to achieve some of the highest clinical outcomes in the nation.
To schedule a comprehensive diagnostic evaluation, or a second-opinion consultation with a Hoag gastroesophageal expert, call us at: 888-566-9712.
When it comes to esophageal cancer and other gastroesophageal conditions, expert evaluation is vital to accurately diagnose esophageal cancer and then determine the best course of treatment for the individual patient.
At Hoag, our multidisciplinary team of gastroesophageal experts works together to thoroughly review and determine the best treatment option suited to each individual patient. The Hoag team then carefully tailors a personalized treatment plan to effectively achieve the best possible outcome for the patient. This emphasis on a collaborative, comprehensive approach to patient-centered care is why Hoag patient outcomes rank are among the nation’s best.
Once esophageal cancer is diagnosed, important staging tests are performed to determine if the cancer has spread, and if so, to what extent. The type of treatment recommended depends upon the stage of the cancer and may include options such as:
Minimally Invasive Transhiatal Esophagectomy
Minimally Invasive Vagal Sparing Esophagectomy
En Bloc Esophagectomy
Endoscopic Mucosal Resection and Ablation Procedures
Chemotherapy
Radiation Therapy
The most recommended treatment for esophageal cancer is complete surgical resection of the esophagus, which is called an esophagectomy. However, in some cases, other more conservative surgical approaches are employed with the goal of preserving as much healthy esophageal tissue as possible. At Hoag, our academic-level team of esophageal experts carefully tailors the treatment plan to the unique needs of each individual patient.
Some of the advanced surgical options for treating esophageal cancer at the Hoag-USC Surgical Center for Digestive Diseases include:
A transhiatal esophagectomy involves removing the esophagus and surrounding lymph nodes completely from the abdomen and reconstructing it using the gastric tube, which is connected to healthy esophagus in the neck. For this procedure, a chest incision is not required. In addition, the esophageal experts at Hoag perform this procedure laparoscopically in most patients.
A vagal sparing esophagectomy involves stripping out the lining of the esophagus and leaving behind the muscular tube. It differs from other esophageal surgery because it preserves the vagus nerves. These nerves are important for normal stomach function, as these nerves allow the stomach to empty properly. For this procedure, a chest incision is not required. In addition, the esophageal experts at Hoag perform this procedure laparoscopically in most patients. This option is most often recommended for patients with benign disease, or those with early-stage cancer of the esophagus.
The most aggressive treatment of esophageal cancer is the en bloc esophagectomy. The philosophy behind this operation is to not only remove the esophagus, but also to remove as much of the lymph node tissue surrounding the esophagus as possible, in order to remove all potential regional sites of tumor spread and thereby maximize the chances of cure. This is a highly complex procedure that requires the expertise of a highly experienced surgical team, as this procedure requires opening the neck, chest and abdomen, in order to reconstruct the esophagus using part of the stomach.
It’s important to note that esophagectomy is a highly complex operation that should only be done at centers with high volume and experience.
When it comes to advanced surgical care, the Hoag team performs more complex esophageal surgeries than any other surgical program in Southern California including state-of-the-art minimally-invasive procedures that may not be available at most centers. Being a high-volume esophageal cancer surgical program enables the gastrointestinal experts at Hoag to achieve a technical skill level not all facilities can match.
Hoag provides a full array of innovative non-surgical treatment options, including:
For very early cancers that are limited to the superficial layer of the esophagus, endoscopic technology has emerged to treat the cancer and preserve the esophagus. This includes the use of endoscopic mucosal resection (EMR) and endoscopic mucosal ablation procedures such as Barrx ablation, which utilizes high frequency radio wave energy to destroy abnormal tissue.
Unlike an esophagectomy, which removes the entire affected area, EMR, ablation and other similar procedures only remove a small cancer, or locally high-grade area of abnormal cells, such as occur with Barrett’s esophagus or early intramucosal cancer. Once successfully treated, patients often require an antireflux operation to protect the esophagus from ongoing injury from reflux.
Chemotherapy is the use of drugs to kill cancer cells. The drugs enter the bloodstream and travel through the body killing mostly cancer cells, but also some healthy cells. Chemotherapy may be used after surgery (often along with radiation therapy) to try to lower the risk of cancer recurrence. Or it may be used before surgery for borderline resectable cancers to try to improve the odds that surgery will be successful. In addition, chemotherapy may be used (with or without radiation therapy) for more advanced cancers, or in cases of metastatic disease.
Radiation therapy uses radiation to kill cancer cells and shrink tumors. Radiation therapy may be used after surgery (often along with chemotherapy) to try to lower the risk of cancer recurrence. Or it may be used in select cases to help control metastases that are too large to be treated effectively with surgery alone, or in cases where surgery is not possible. As a nationally recognized leader in state-of-the-art radiation therapies, Hoag’s Radiation Oncology Program is yet another example of the institute’s commitment to excellence in innovative cancer treatment.
When it comes to seeking out the most advanced academic-level gastroesophageal care, there is no longer any need to travel long distances. Hoag offers the latest in state-of-the-art diagnosis and leading-edge treatment options that may not be readily available at other centers, including participation in clinical trials that helps to bring advanced gastroesophageal care to even more patients.
Perhaps the most distinguishing aspect of Hoag’s advanced treatment of gastroesophageal conditions is that in each and every case, treatment is always specifically tailored to the meet the unique needs of the individual patient.
Hoag continues to lead the way in complex gastroesophageal care, providing access to a highly specialized surgical team that works collaboratively with Hoag-affiliated thoracic surgeons, gastroenterologists and medical oncology specialists to provide academic-level care. Hoag’s committed to accurate diagnosis, combined with progressive therapeutic options enables Hoag patients to achieve some of the highest clinical outcomes in the nation.
To schedule a comprehensive diagnostic evaluation, or a second-opinion consultation with a Hoag gastroesophageal expert, call us at: 888-566-9712.

<div> <p dir="ltr"><span>Matthew D. Stanley, M.D., is a fellowship-trained thoracic surgeon at Hoag Family Cancer Institute. Dr. Stanley’s areas of expertise include robotic surgical techniques and minimally invasive surgery. He specializes in treatment of esophageal and lung cancer, gastroesophageal reflux disease (GERD), achalasia, paraoesophageal and hiatal hernias, mediastinal tumors and airway disease.</span></p> <p></p> <p dir="ltr"><span>Dr. Stanley completed his cardiothoracic surgery fellowship and general surgery residency at Emory University School of Medicine in Atlanta, Georgia. During his final year of training, he was selected by his peers to serve as administrative chief fellow. During residency, he completed a post-doctoral research fellowship. He earned his medical degree at the University of Kentucky College of Medicine in Lexington, Kentucky.</span></p> <p></p> <p dir="ltr"><span>Dr. Stanley completed the Thoracic Surgical Robotics Fellowship under the American Association for Thoracic Surgery and Intuitive Surgical. In 2023, he received the House Staff organization Professionalism Excellence (HOPE) Award at Emory, honoring his exceptional professionalism in working with patients and colleagues.</span></p> <p dir="ltr"></p> <p dir="ltr"><span>Dr. Stanley has authored or co-authored several book chapters, peer-reviewed publications and oral presentations. He is a member of the Society of Thoracic Surgeons and the American College of Surgeons. </span></p> <p dir="ltr"></p> <p dir="ltr"><span>In his spare time, Dr. Stanley enjoys travel, running, skiing, physical fitness, college athletics and spending time with his wife and daughter.</span></p> </div>

Katherine Blevins, M.D., Ph.D. is a minimally invasive surgeon (MIS) with a focus in bariatric, foregut and advanced gastrointestinal surgery. She is board certified in general surgery, and is fellowship trained in advanced GI, MIS and bariatric surgery. She holds certificates for Advanced GI MIS Surgery from SAGES, as well as the ASMBS Fellowship Certificate for Bariatric Surgery. She is skilled in both laparoscopic and robotic techniques. Dr. Blevins completed her general surgery residency training at Stanford University. During her training, she spent two years in professional development as a fellow in the Stanford Biodesign Innovation Fellowship, a project based medical technology innovation program where she was trained in medical technology innovation from idea to implementation. She completed advanced clinical training as a clinical fellow in advanced GI/MIS and Bariatric Surgery at Cedars Sinai Medical Center, one of the highest ranked fellowship programs for GI surgery in the country. Dr. Blevins’ research interests include medical technology innovation as well as patient outcomes after bariatric surgery. She has co-authored multiple peer-reviewed journal articles and book chapters and has directed and collaborated with teams in many stages of medical technology innovation. Dr. Blevins attended University of California, Irvine for her undergraduate education, where she earned a bachelor’s degree in biomedical engineering. She earned her doctorate degree in bioengineering with an emphasis in biomaterials from the University of Utah. Her dissertation focused on designing novel targeted gene delivery systems to prevent type 1 diabetes. During her Ph.D. work, she discovered her love for the translational aspects of research and chose to expand her background in clinical medicine. She attended medical school at the University of Utah where she was elected into Alpha Omega Alpha. During her clinical years, she was drawn to surgery. One of her favorite parts of surgery is the ability to work with patients to help solve their problems. Her long-term goals are to integrate clinical practice as a surgeon with advancing innovation in medical technology.

<p>Tara Seery, M.D., attended University College Dublin School of Medicine followed by an internship at Mater Misericordiae Hospital as well as an internship and residency at Caritas St. Elizabeth Medical Center in Boston. She then completed fellowships in hematology/oncology at both Caritas St. Elizabeth Medical Center and University of Illinois at Chicago. Dr. Seery is board certified in Medical Oncology and Hematology.</p><p>Dr. Seery is particularly interested in GI oncology, including hepatobiliary cancers such as pancreatic, liver and bile duct cancers.</p><p>She has served as the primary investigator on several clinical research trials, co-authored numerous medical publications and abstracts, and edited multiple peer-reviewed journals. Additionally, she has given clinical presentations both across the U.S. and abroad. </p><p>Dr. Seery’s teaching experience spans the areas of medical and graduate level courses including a Hematology/Oncology Fellowship Annual Lecture Series on Pancreatic Cancer, Liver Cancer and the Management of Unresectable Hepatocellular Carcinoma at UC Irvine’s 5th Annual Gastroenterology and Hepatology Symposium. In addition, she oversaw a group of Hematology/Oncology Fellows at the University of California Irvine Outpatient Clinic.</p><p>Dr. Seery is a member of the American Society of Clinical Oncology and the American Society of Hematology.</p>

Medical Director of Cancer Research for Hoag Family Cancer Institute

Executive Medical Director, Hoag Digestive Health Institute

Medical Director of Hoag Advanced Endoscopy Center, Gastroenterologist

Paul J. Korc, M.D. serves as medical director of the Hoag GI Lab and is a board-certified gastroenterologist with fellowship training in advanced endoscopic procedures. After completing his residency and fellowship at USC, he went on to spend a year at Indiana University, one of the nation’s top programs for biliary and pancreatic disorders. There, he received training in endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasound (EUS), gaining extensive experience in the management of complex cases. Dr. Korc’s expertise also includes removal of large polyps and early stage cancers of the gastrointestinal tract, using endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD). He spent time in Seoul, Korea learning ESD, a cutting-edge technique in which pre-cancerous lesions and superficial cancers are removed en bloc (in one piece), avoiding the need for surgery. Additionally, Dr. Korc performs peroral endoscopic myotomy (POEM), a specialized procedure that restores the ability to eat and drink for people with achalasia, an esophageal motility disorder. Dr. Korc brings to Hoag his expertise in these procedures, some of which are available at only a handful of medical centers in Southern California. Dr. Korc offers patients compassionate, personalized care along with the very best advances in endoscopic treatment.
Hoag’s Precision Medicine Program combines genomics and genetics to diagnose, treat, and prevent diseases. Using the latest advances in genomic technologies, targeted therapies and research, our precision medicine program brings together a multidisciplinary team, including a robust genetic counseling group of experts, to provide patients with the latest in innovation and technology.
Being diagnosed with cancer can feel overwhelming at times. Many patients and their families need help with coping and can benefit from supportive counseling. Oncology Clinical Social Workers are available to provide emotional and practical support during all stages of cancer including diagnosis, treatment and post-treatment survivorship.
Hoag Family Cancer Institute dietitians work closely with patients’ physicians, nurses, therapists, and social workers to ensure complete care.
Hoag leads innovative clinical trials, including immunotherapy agents, all pushing for more advanced, effective care for esophageal cancer patients.
Click here to learn more on clinical trials for esophageal cancer.